0 624Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 60,653 European ancestry cases, 804,329 European ancestry controls, 368 Latino cases, 3,976 Latino controls, 863 mixed ancestry cases, 1,273 mixed ancestry controls, 2,385 Japanese ancestry cases, 209,651 Japanese ancestry controls, 838 African American cases, 2,058 African American controls; replicated in 387,407 European ancestry cases, 2,517,257 European ancestry controls, 25,813 African ancestry cases, 148,202 African ancestry controls, 58,909 Latino cases, 466,439 Latino controls.
The effect
The reported allele is G; the catalogue records no effect size
; p = 3 × 10−12.
How common The G allele had a frequency of about 43% in the people studied.
Where it sits Chromosome 11, band 11p15.4 — between genes, 1.9 kb from NLRP10.
What each result means
G/GTwo copies of the version the research linked to Atopic dermatitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Atopic dermatitis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Atopic dermatitis. This is the starting point the study compared everyone against.
Nature communications · 2023 · PMID 37794016 · open access
Questions about rs4312054
What is rs4312054?
rs4312054 is a single position in the genome, in or near the near NLRP10 gene. Published research associates it with atopic dermatitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4312054 linked to?
On MyGeneLog this position is linked to Atopic Dermatitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs4312054 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4312054 come from?
GWAS Catalog, Nature communications 2023, PMID:37794016. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 624Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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