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Who was studied 17,803 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 1.51 lower (95% confidence interval 1.06-1.96); p = 4 × 10−11.
How common The T allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 10, band 10q26.13 — in an intron of PLEKHA1.
What each result means
C/CNo copy of the version the research linked to Central corneal thickness (MTAG). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Central corneal thickness (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Central corneal thickness (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs4311997 is a single position in the genome, in or near the PLEKHA1 gene. Published research associates it with central corneal thickness (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4311997 linked to?
On MyGeneLog this position is linked to Central Corneal Thickness. The research behind each link, and its sources, are set out on that condition page.
Does having rs4311997 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4311997 come from?
GWAS Catalog, JAMA ophthalmology 2022, PMID:35446358. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Central corneal thickness (MTAG) (rs4311997). MyGeneLog™. https://www.mygenelog.com/variants/rs4311997