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Medication use (calcium channel blockers)

ACE · rs4305

Where this position leads

Condition: Medication Use as a Genetic Trait

What the study found

Who was studied 31,904 European ancestry cases, 172,474 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0597 higher (95% confidence interval 0.044-0.076); p = 3 × 10⁻¹³.

How common The A allele had a frequency of about 44% in the people studied.

Where it sits Chromosome 17, band 17q23.3 — in an intron of ACE.

What ClinVar records

Classification Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-11-10. ClinVar record 1278455 NM_000789.4(ACE):c.848-223A>G

What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Medication use (calcium channel blockers) compared to the general population.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Medication use (calcium channel blockers).

G/G Published research associates this genotype with typical/baseline likelihood of Medication use (calcium channel blockers) — no copies of the reported risk allele.

Source

Genome-wide association study of medication-use and associated disease in the UK Biobank

Wu Y, Byrne EM, Zheng Z, Kemper KE, Yengo L, Mallett AJ, Yang J, Visscher PM, Wray NR

Nature communications · 2019 · PMID 31015401 · open access

Questions about rs4305

What is rs4305?

rs4305 is a single position in the genome, in or near the ACE gene. Published research associates it with medication use (calcium channel blockers). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4305 linked to?

On MyGeneLog this position is linked to Medication Use as a Genetic Trait. The research behind each link, and its sources, are set out on that condition page.

Does having rs4305 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4305 come from?

GWAS Catalog, Nat Commun 2019, PMID:31015401. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Medication use (calcium channel blockers) (rs4305). MyGeneLog™. https://www.mygenelog.com/variants/rs4305

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