NDRG4 · rs42945
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 194,453 European ancestry men.
The effect Each copy of the A allele shifted the measure 0.0162 higher (95% confidence interval 0.01-0.022); p = 4 × 10−8.
How common The A allele had a frequency of about 49% in the people studied.
Where it sits Chromosome 16, band 16q21 — a synonymous change in NDRG4.
What ClinVar records
Classification
Benign for NDRG4-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2019-01-10.
ClinVar record 1282475 NM_001242835.2(NDRG4):c.1005A>G (p.Ser335=)
What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs42945 is a single position in the genome, in or near the NDRG4 gene. Published research associates it with total testosterone levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature medicine 2020, PMID:32042192. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Total testosterone levels (rs42945). MyGeneLog™. https://www.mygenelog.com/variants/rs42945