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DNA methylation PhenoAge acceleration

near NHLRC1 · rs4294009

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 34,463 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.336 higher (95% confidence interval 0.26-0.41); p = 1 × 10⁻¹⁷.

How common The G allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 6, band 6p22.3 — between genes, 14.6 kb from NHLRC1.

What each result means

G/G Two copies of the version the research linked to DNA methylation PhenoAge acceleration. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to DNA methylation PhenoAge acceleration. That is a smaller link than two copies.

T/T No copy of the version the research linked to DNA methylation PhenoAge acceleration. This is the starting point the study compared everyone against.

Source

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

McCartney DL, Min JL, Richmond RC, Lu AT, Sobczyk MK, Davies G, Broer L, Guo X, Jeong A, Jung J, Kasela S, Katrinli S

and 97 more — show all

Kuo PL, Matias-Garcia PR, Mishra PP, Nygaard M, Palviainen T, Patki A, Raffield LM, Ratliff SM, Richardson TG, Robinson O, Soerensen M, Sun D, Tsai PC, van der Zee MD, Walker RM, Wang X, Wang Y, Xia R, Xu Z, Yao J, Zhao W, Correa A, Boerwinkle E, Dugué PA, Durda P, Elliott HR, Gieger C, de Geus EJC, Harris SE, Hemani G, Imboden M, Kähönen M, Kardia SLR, Kresovich JK, Li S, Lunetta KL, Mangino M, Mason D, McIntosh AM, Mengel-From J, Moore AZ, Murabito JM, Ollikainen M, Pankow JS, Pedersen NL, Peters A, Polidoro S, Porteous DJ, Raitakari O, Rich SS, Sandler DP, Sillanpää E, Smith AK, Southey MC, Strauch K, Tiwari H, Tanaka T, Tillin T, Uitterlinden AG, Van Den Berg DJ, van Dongen J, Wilson JG, Wright J, Yet I, Arnett D, Bandinelli S, Bell JT, Binder AM, Boomsma DI, Chen W, Christensen K, Conneely KN, Elliott P, Ferrucci L, Fornage M, Hägg S, Hayward C, Irvin M, Kaprio J, Lawlor DA, Lehtimäki T, Lohoff FW, Milani L, Milne RL, Probst-Hensch N, Reiner AP, Ritz B, Rotter JI, Smith JA, Taylor JA, van Meurs JBJ, Vineis P, Waldenberger M, Deary IJ, Relton CL, Horvath S, Marioni RE

Genetics of DNA Methylation Consortium · NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

Genome biology · 2021 · PMID 34187551 · open access

Questions about rs4294009

What is rs4294009?

rs4294009 is a single position in the genome, in or near the near NHLRC1 gene. Published research associates it with dna methylation phenoage acceleration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4294009 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4294009 come from?

GWAS Catalog, Genome biology 2021, PMID:34187551. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

DNA methylation PhenoAge acceleration (rs4294009). MyGeneLog™. https://www.mygenelog.com/variants/rs4294009

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