Sensitive

Alzheimer's disease risk (APOE)

APOE · rs429358-rs7412

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Where this position leads

Condition: Alzheimer's Disease Risk (APOE)

Drug: Lecanemab and other anti-amyloid antibodies

rs429358-rs7412 Condition: Alzheimer's Disease Risk (APOE) Alzheimer's Disease Risk (APOE) Condition Drug: Lecanemab and other anti-amyloid antibodies Lecanemab and other anti-amyloid antibodies Drug rs429358-rs7412 APOE

What each result means

e2/e3 Published research associates this genotype with somewhat reduced lifetime risk compared to baseline.
e3/e3 The most common genotype. Published research treats this as the baseline (average) risk level.
e3/e4 One copy of the e4 allele. Published research associates this genotype with moderately elevated lifetime risk of late-onset Alzheimer's disease compared to baseline.
e4/e4 Two copies of the e4 allele. Published research associates this genotype with substantially elevated lifetime risk of late-onset Alzheimer's disease compared to baseline.
This result does not predict whether or when Alzheimer's disease will occur. Talk to a doctor or a genetic counselor about what this means for you and your family.

Source: Corder et al. 1993, Science — gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease.

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