0 826Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others6Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 12,346 East Asian ancestry cases, 225,690 East Asian ancestry controls, 10,976 European ancestry cases, 260,520 European ancestry controls.
The effect
Each copy of the A allele carried 0.93 times the odds of Lung adenocarcinoma (95% confidence interval 0.91-0.96); p = 2 × 10−8.
How common The A allele had a frequency of about 59% in the people studied.
Where it sits Chromosome 11, band 11q23.3 — between genes, 4 kb from SETP16.
What each result means
A/ATwo copies of the version the research linked to Lung adenocarcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Lung adenocarcinoma. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Lung adenocarcinoma. This is the starting point the study compared everyone against.
Genome medicine · 2026 · PMID 42152146 · open access
Questions about rs4291686
What is rs4291686?
rs4291686 is a single position in the genome, in or near the near SETP16 gene. Published research associates it with lung adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4291686 linked to?
On MyGeneLog this position is linked to EGFR Mutation-Positive Lung Adenocarcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs4291686 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4291686 come from?
GWAS Catalog, Genome medicine 2026, PMID:42152146. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 826Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others6Total8Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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