Standard

Externalizing behaviour (multivariate analysis)

near LINC00938 · rs4285945

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied up to 53,293 European ancestry Attention-deficit/hyperactivity disorder individuals, up to 164,684 European ancestry problematic alcohol use individuals, up to 186,875 European ancestry lifetime cannabis use individuals, up to 357,187 European ancestry individuals measuring reverse-coded age at first sexual intercourse, up to 336,121 European ancestry individuals measuring number of sexual partners, up to 426,379 European ancestry individuals measuring general risk tolerance, up to 1,251,809 European ancestry individuals measuring lifetime smoking initiation.

The effect Each copy of the A allele shifted the measure 0.01 lower (95% confidence interval 0.008-0.012); p = 5 × 10⁻¹¹.

How common The A allele had a frequency of about 77% in the people studied.

Where it sits Chromosome 12, band 12q12 — between genes, 6 kb from LINC00938.

What each result means

A/A Two copies of the version the research linked to Externalizing behaviour (multivariate analysis). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Externalizing behaviour (multivariate analysis). That is a smaller link than two copies.

G/G No copy of the version the research linked to Externalizing behaviour (multivariate analysis). This is the starting point the study compared everyone against.

Source

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M

and 17 more — show all

Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM

COGA Collaborators

Nature neuroscience · 2021 · PMID 34446935 · open access

Questions about rs4285945

What is rs4285945?

rs4285945 is a single position in the genome, in or near the near LINC00938 gene. Published research associates it with externalizing behaviour (multivariate analysis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4285945 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4285945 come from?

GWAS Catalog, Nature neuroscience 2021, PMID:34446935. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Externalizing behaviour (multivariate analysis) (rs4285945). MyGeneLog™. https://www.mygenelog.com/variants/rs4285945

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