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Who was studied 46,904 European ancestry males; replicated in 80,822 European ancestry males.
The effect
Each copy of the A allele shifted the measure 0.0385 higher; p = 1 × 10−19.
How common The A allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 1, band 1q32.3 — in an intron of PROX1.
What each result means
A/ATwo copies of the version the research linked to Hemoglobin concentration. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Hemoglobin concentration. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Hemoglobin concentration. This is the starting point the study compared everyone against.
The Journal of nutritional biochemistry · 2023 · PMID 35964923
Questions about rs4282786
What is rs4282786?
rs4282786 is a single position in the genome, in or near the PROX1 gene. Published research associates it with hemoglobin concentration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4282786 linked to?
On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs4282786 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4282786 come from?
GWAS Catalog, The Journal of nutritional biochemistry 2023, PMID:35964923. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 122217Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others7Total12Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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