Sensitive

Sjögren's syndrome

COL11A2 · rs4282438

Where this position leads

What the study found

Who was studied 542 Han Chinese ancestry cases, 1,050 Han Chinese ancestry controls; replicated in 1,303 Han Chinese ancestry cases, 2,727 Han Chinese ancestry controls.

The effect Each copy of the G allele carried 1.58 times the odds of Sjögren's syndrome (95% confidence interval 1.45-1.72); p = 9 × 10⁻²⁵.

How common The G allele had a frequency of about 35% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in an intron of COL11A2P1.

What each result means

G/G Two copies of the version the research linked to Sjögren's syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.

G/T One copy of the version the research linked to Sjögren's syndrome. That is a smaller link than two copies.

T/T No copy of the version the research linked to Sjögren's syndrome. This is the starting point the study compared everyone against.

Source

A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23

Li Y, Zhang K, Chen H, Sun F, Xu J, Wu Z, Li P, Zhang L, Du Y, Luan H, Li X, Wu L

and 64 more — show all

Li H, Wu H, Li X, Li X, Zhang X, Gong L, Dai L, Sun L, Zuo X, Xu J, Gong H, Li Z, Tong S, Wu M, Li X, Xiao W, Wang G, Zhu P, Shen M, Liu S, Zhao D, Liu W, Wang Y, Huang C, Jiang Q, Liu G, Liu B, Hu S, Zhang W, Zhang Z, You X, Li M, Hao W, Zhao C, Leng X, Bi L, Wang Y, Zhang F, Shi Q, Qi W, Zhang X, Jia Y, Su J, Li Q, Hou Y, Wu Q, Xu D, Zheng W, Zhang M, Wang Q, Fei Y, Zhang X, Li J, Jiang Y, Tian X, Zhao L, Wang L, Zhou B, Li Y, Zhao Y, Zeng X, Ott J, Wang J, Zhang F

Nature genetics · 2013 · PMID 24097066

Questions about rs4282438

What is rs4282438?

rs4282438 is a single position in the genome, in or near the COL11A2 gene. Published research associates it with sjögren's syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4282438 linked to?

On MyGeneLog this position is linked to Sjögren's Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs4282438 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4282438 come from?

GWAS Catalog, Nature genetics 2013, PMID:24097066. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Sjögren's syndrome (rs4282438). MyGeneLog™. https://www.mygenelog.com/variants/rs4282438

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