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Intracranial volume

RNF146 · rs4273712

What the study found

Who was studied 8,175 European ancestry individuals; replicated in 1,752 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 12.5 ml higher; p = 2 × 10−13.

How common The G allele had a frequency of about 27% in the people studied.

Where it sits Chromosome 6, band 6q22.32 — between genes, 0.1 kb from PRELID1P1.

What each result means

A/A No copy of the version the research linked to Intracranial volume. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Intracranial volume. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Intracranial volume. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4273712

What is rs4273712?

rs4273712 is a single position in the genome, in or near the RNF146 gene. Published research associates it with intracranial volume. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs4273712?

Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4273712 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4273712 come from?

GWAS Catalog, Nat Genet 2012, PMID:22504418. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Intracranial volume (rs4273712). MyGeneLog™. https://www.mygenelog.com/variants/rs4273712

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