3 5222428223225Reads by AI crawlersClaude2ChatGPT2Google · Gemini4Perplexity2Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others25Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,618 European ancestry cases, 42,881 European ancestry controls; replicated in 3,231 European ancestry cases, 3,536 European ancestry controls.
The effect
Each copy of the G allele carried 1.24 times the odds of Venous thromboembolism (95% confidence interval 1.17-1.31); p = 3 × 10−14.
How common The G allele had a frequency of about 61% in the people studied.
Where it sits Chromosome 4, band 4q35.2 — in an intron of F11.
What ClinVar records
ClassificationBenign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2021-05-11.
ClinVar record 1296768NM_000128.4(F11):c.-1-196T>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
G/GTwo copies of the version the research linked to Venous thromboembolism. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/TOne copy of the version the research linked to Venous thromboembolism. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Venous thromboembolism. This is the starting point the study compared everyone against.
rs4253399 is a single position in the genome, in or near the F11 gene. Published research associates it with venous thromboembolism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4253399 linked to?
On MyGeneLog this position is linked to Venous Thromboembolism. The research behind each link, and its sources, are set out on that condition page.
Does having rs4253399 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4253399 come from?
GWAS Catalog, Genet Epidemiol 2013, PMID:23650146. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 5222428223225Reads by AI crawlersClaude2ChatGPT2Google · Gemini4Perplexity2Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others25Total52Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.