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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,498 European ancestry cases, 15,550 European ancestry controls.
The effect
Each copy of the C allele carried 1.25 times the odds of Giant cell arteritis (95% confidence interval 1.18-1.32); p = 1 × 10−13.
Where it sits Chromosome 6, band 6q26 — in an intron of PLG.
What each result means
C/CTwo copies of the version the research linked to Giant cell arteritis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Giant cell arteritis. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Giant cell arteritis. This is the starting point the study compared everyone against.
The Lancet. Rheumatology · 2024 · PMID 38734017 · open access
Questions about rs4252114
What is rs4252114?
rs4252114 is a single position in the genome, in or near the PLG gene. Published research associates it with giant cell arteritis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4252114 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4252114 come from?
GWAS Catalog, The Lancet. Rheumatology 2024, PMID:38734017. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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