4 452228223123Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others23Total45Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,119 Japanese ancestry cases, 2,718 Japanese ancestry controls; replicated in 432 Japanese ancestry cases, 1,157 Japanese ancestry controls.
The effect
Each copy of the C allele carried 1.38 times the odds of Graves' disease (95% confidence interval 1.27-1.50); p = 1 × 10−13.
How common The C allele had a frequency of about 54% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — a synonymous change in MUC22.
What each result means
C/CTwo copies of the version the research linked to Graves' disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Graves' disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Graves' disease. This is the starting point the study compared everyone against.
rs4248154 is a single position in the genome, in or near the MHC gene. Published research associates it with graves' disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4248154 linked to?
On MyGeneLog this position is linked to Graves' Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs4248154 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4248154 come from?
GWAS Catalog, J Hum Genet 2011, PMID:21900946. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 452228223123Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others23Total45Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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