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Who was studied 418,642 British ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0128 lower (95% confidence interval 0.0085-0.017); p = 4 × 10−9.
How common The C allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 9, band 9p22.3 — in an intron of NFIB-AS1.
What each result means
C/CTwo copies of the version the research linked to C-reactive protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to C-reactive protein levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to C-reactive protein levels. This is the starting point the study compared everyone against.
European journal of epidemiology · 2020 · PMID 31900758
Questions about rs424539
What is rs424539?
rs424539 is a single position in the genome, in or near the NFIB-AS1 gene. Published research associates it with c-reactive protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs424539 linked to?
On MyGeneLog this position is linked to C-Reactive Protein Levels. The research behind each link, and its sources, are set out on that condition page.
Does having rs424539 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs424539 come from?
GWAS Catalog, European journal of epidemiology 2020, PMID:31900758. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1522227Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others7Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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C-reactive protein levels (rs424539). MyGeneLog™. https://www.mygenelog.com/variants/rs424539