Who was studied 344,104 European ancestry individuals, 150,266 East Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0156 lower (95% confidence interval 0.012-0.019); p = 7 × 10−22.
Where it sits Chromosome 18, band 18q21.1 — in an intron of SMAD7.
What each result means
A/APublished research associates this genotype with typical/baseline likelihood of Serum creatinine levels — no copies of the reported risk allele.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Serum creatinine levels.
G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Serum creatinine levels compared to the general population.
rs4245230 is a single position in the genome, in or near the SMAD7 gene. Published research associates it with serum creatinine levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4245230 linked to?
On MyGeneLog this position is linked to Colon Polyp. The research behind each link, and its sources, are set out on that condition page.
Does having rs4245230 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4245230 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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