Standard

Body mass index

ADAM10 · rs4238331

Where this position leads

Condition: Obesity and Body Weight

rs4238331 Condition: Obesity and Body Weight Obesity and Body Weight Condition rs4238331 rs4238331 ADAM10

What the study found

Who was studied 315,347 European ancestry individuals, 8,322 Hispanic/Latino individuals, 7,290 East Asian ancestry individuals, 3,069 African American individuals, 459 South Asian ancestry individuals; replicated in 431,743 European ancestry individuals, 9,275 South Asian ancestry individuals, 8,261 African British individuals, 1,822 East Asian ancestry individuals, 7,620 individuals.

The effect Each copy of the T allele shifted the measure 0.011 lower; p = 5 × 10−9.

Where it sits Chromosome 15, band 15q21.3 — in an intron of ADAM10.

What each result means

G/G No copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Body mass index. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4238331

What is rs4238331?

rs4238331 is a single position in the genome, in or near the ADAM10 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4238331 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs4238331 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4238331 come from?

GWAS Catalog, Genetics 2018, PMID:30108127. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (rs4238331). MyGeneLog™. https://www.mygenelog.com/variants/rs4238331

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