Sensitive

Bipolar disorder

MAD1L1 · rs4236274

Where this position leads

What the study found

Who was studied 7,647 European ancestry cases, 27,303 European ancestry controls; replicated in 2,137 European ancestry cases, 3,168 European ancestry controls.

The effect Each copy of the G allele carried 1.15 times the odds of Bipolar disorder (95% confidence interval 1.10-1.20); p = 8 × 10⁻¹².

How common The G allele had a frequency of about 39% in the people studied.

Where it sits Chromosome 7, band 7p22.3 — in an intron of MAD1L1.

What each result means

A/A No copy of the version the research linked to Bipolar disorder. This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Bipolar disorder. That is a smaller link than two copies.

G/G Two copies of the version the research linked to Bipolar disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

Hou L, Bergen SE, Akula N, Song J, Hultman CM, Landén M, Adli M, Alda M, Ardau R, Arias B, Aubry JM, Backlund L

and 127 more — show all

Badner JA, Barrett TB, Bauer M, Baune BT, Bellivier F, Benabarre A, Bengesser S, Berrettini WH, Bhattacharjee AK, Biernacka JM, Birner A, Bloss CS, Brichant-Petitjean C, Bui ET, Byerley W, Cervantes P, Chillotti C, Cichon S, Colom F, Coryell W, Craig DW, Cruceanu C, Czerski PM, Davis T, Dayer A, Degenhardt F, Del Zompo M, DePaulo JR, Edenberg HJ, Étain B, Falkai P, Foroud T, Forstner AJ, Frisén L, Frye MA, Fullerton JM, Gard S, Garnham JS, Gershon ES, Goes FS, Greenwood TA, Grigoroiu-Serbanescu M, Hauser J, Heilbronner U, Heilmann-Heimbach S, Herms S, Hipolito M, Hitturlingappa S, Hoffmann P, Hofmann A, Jamain S, Jiménez E, Kahn JP, Kassem L, Kelsoe JR, Kittel-Schneider S, Kliwicki S, Koller DL, König B, Lackner N, Laje G, Lang M, Lavebratt C, Lawson WB, Leboyer M, Leckband SG, Liu C, Maaser A, Mahon PB, Maier W, Maj M, Manchia M, Martinsson L, McCarthy MJ, McElroy SL, McInnis MG, McKinney R, Mitchell PB, Mitjans M, Mondimore FM, Monteleone P, Mühleisen TW, Nievergelt CM, Nöthen MM, Novák T, Nurnberger JI Jr, Nwulia EA, Ösby U, Pfennig A, Potash JB, Propping P, Reif A, Reininghaus E, Rice J, Rietschel M, Rouleau GA, Rybakowski JK, Schalling M, Scheftner WA, Schofield PR, Schork NJ, Schulze TG, Schumacher J, Schweizer BW, Severino G, Shekhtman T, Shilling PD, Simhandl C, Slaney CM, Smith EN, Squassina A, Stamm T, Stopkova P, Streit F, Strohmaier J, Szelinger S, Tighe SK, Tortorella A, Turecki G, Vieta E, Volkert J, Witt SH, Wright A, Zandi PP, Zhang P, Zollner S, McMahon FJ

Human molecular genetics · 2016 · PMID 27329760

Questions about rs4236274

What is rs4236274?

rs4236274 is a single position in the genome, in or near the MAD1L1 gene. Published research associates it with bipolar disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4236274 linked to?

On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.

Does having rs4236274 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4236274 come from?

GWAS Catalog, Hum Mol Genet 2016, PMID:27329760. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bipolar disorder (rs4236274). MyGeneLog™. https://www.mygenelog.com/variants/rs4236274

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