APOC3 · rs4225
Where this position leads
Condition: Cholesterol (LDL, HDL and Total)
What the study found
Who was studied 241,027 British ancestry females.
The effect Each copy of the T allele shifted the measure 0.0593 mmol/L lower (95% confidence interval 0.054-0.065); p = 5 × 10−92.
Where it sits Chromosome 11, band 11q23.3 — in the 3′ untranslated region of APOC3.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2018-08-30.
ClinVar record 1225805 NM_000040.3(APOC3):c.*71G>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs4225 is a single position in the genome, in or near the APOC3 gene. Published research associates it with concentration of hdl particles. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Concentration of HDL particles (rs4225). MyGeneLog™. https://www.mygenelog.com/variants/rs4225