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Colon polyp

near FADS3 · rs422249

Where this position leads

Condition: Colon Polyp

rs422249 Condition: Colon Polyp Colon Polyp Condition rs422249 rs422249 near FADS3

What the study found

Who was studied 22,049 European ancestry cases, 332,368 European ancestry controls, 4,768 East Asian ancestry cases, 166,052 East Asian ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0591 higher (95% confidence interval 0.038-0.08); p = 2 × 10−8.

Where it sits Chromosome 11, band 11q12.2 — between genes, 1.5 kb from FADS3.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Colon polyp compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Colon polyp.
T/T Published research associates this genotype with typical/baseline likelihood of Colon polyp — no copies of the reported risk allele.
Source
A cross-population atlas of genetic associations for 220 human phenotypes
Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A
and 34 more — show all
Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y
FinnGen
Nature genetics · 2021 · PMID 34594039

Questions about rs422249

What is rs422249?

rs422249 is a single position in the genome, in or near the near FADS3 gene. Published research associates it with colon polyp. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs422249 linked to?

On MyGeneLog this position is linked to Colon Polyp. The research behind each link, and its sources, are set out on that condition page.

Does having rs422249 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs422249 come from?

GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Colon polyp (rs422249). MyGeneLog™. https://www.mygenelog.com/variants/rs422249

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