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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 389,565 European ancestry individuals; replicated in 134,182 East Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 6.65 z-score higher; p = 3 × 10−11.
How common The T allele had a frequency of about 95% in the people studied.
Where it sits Chromosome 13, band 13q34 — in an intron of CARS2.
What each result means
C/CNo copy of the version the research linked to Aspartate aminotransferase levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Aspartate aminotransferase levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Aspartate aminotransferase levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33547301 · open access
Questions about rs421491
What is rs421491?
rs421491 is a single position in the genome, in or near the CARS2 gene. Published research associates it with aspartate aminotransferase levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs421491 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs421491 come from?
GWAS Catalog, Nature communications 2021, PMID:33547301. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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