Standard

Free Cholesterol to Total Lipids in Large VLDL percentage

near FZD9 · rs42122

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

rs42122 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition rs42122 rs42122 near FZD9

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the A allele shifted the measure 0.02 % higher (95% confidence interval 0.02-0.02); p = 3 × 10−12.

Where it sits Chromosome 7, band 7q11.23 — between genes, 6.3 kb from FZD9.

What each result means

A/A Two copies of the version the research linked to Free Cholesterol to Total Lipids in Large VLDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Free Cholesterol to Total Lipids in Large VLDL percentage. That is a smaller link than two copies.
G/G No copy of the version the research linked to Free Cholesterol to Total Lipids in Large VLDL percentage. This is the starting point the study compared everyone against.
Source

Questions about rs42122

What is rs42122?

rs42122 is a single position in the genome, in or near the near FZD9 gene. Published research associates it with free cholesterol to total lipids in large vldl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs42122 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does having rs42122 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs42122 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Free Cholesterol to Total Lipids in Large VLDL percentage (rs42122). MyGeneLog™. https://www.mygenelog.com/variants/rs42122

← See all variants