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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 488 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.339 lower (95% confidence interval 0.25-0.43); p = 7 × 10−13.
Where it sits Chromosome 21, band 21q22.3 — in an intron of ICOSLG.
What each result means
C/CTwo copies of the version the research linked to ICOSLG protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to ICOSLG protein levels. That is a smaller link than two copies.
T/TNo copy of the version the research linked to ICOSLG protein levels. This is the starting point the study compared everyone against.
Scientific reports · 2024 · PMID 38565889 · open access
Questions about rs420726
What is rs420726?
rs420726 is a single position in the genome, in or near the ICOSLG gene. Published research associates it with icoslg protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs420726 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs420726 come from?
GWAS Catalog, Scientific reports 2024, PMID:38565889. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
ICOSLG protein levels (rs420726). MyGeneLog™. https://www.mygenelog.com/variants/rs420726