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Who was studied 42,490 European ancestry cases, 773,420 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.0762 log odds ratio higher (95% confidence interval 0.055-0.097); p = 2 × 10−12.
Where it sits Chromosome 17, band 17q21.32 — in an intron of TBX21.
What each result means
G/GNo copy of the version the research linked to Hashimoto thyroiditis. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Hashimoto thyroiditis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Hashimoto thyroiditis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 42527560 · open access
Questions about rs41519545
What is rs41519545?
rs41519545 is a single position in the genome, in or near the TBX21 gene. Published research associates it with hashimoto thyroiditis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs41519545 linked to?
On MyGeneLog this position is linked to Lymphocytic Thyroiditis (Hashimoto's). The research behind each link, and its sources, are set out on that condition page.
Does having rs41519545 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs41519545 come from?
GWAS Catalog, Nature genetics 2026, PMID:42527560. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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