Sensitive

Systemic lupus erythematosus

near CCL22 · rs4151115

Where this position leads

Condition: Systemic Lupus Erythematosus

rs4151115 Condition: Systemic Lupus Erythematosus Systemic Lupus Erythematosus Condition rs4151115 rs4151115 near CCL22

What the study found

Who was studied 16,491 European ancestry cases, 1,202,106 European ancestry controls, 5,051 East Asian ancestry cases, 185,362 East Asian ancestry controls, 740 African American or Afro-Caribbean cases, 120,993 African American or Afro-Caribbean controls, 212 Hispanic or Latin American cases, 59,641 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 0.123 higher (95% confidence interval 0.072-0.174); p = 3 × 10−10.

Where it sits Chromosome 16, band 16q21 — between genes, 0.1 kb from CCL22.

What each result means

C/C Two copies of the version the research linked to Systemic lupus erythematosus. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Systemic lupus erythematosus. That is a smaller link than two copies.
T/T No copy of the version the research linked to Systemic lupus erythematosus. This is the starting point the study compared everyone against.
Source

Questions about rs4151115

What is rs4151115?

rs4151115 is a single position in the genome, in or near the near CCL22 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4151115 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs4151115 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4151115 come from?

GWAS Catalog, Mammalian genome : official journal of the International Mammalian Genome Society 2026, PMID:42581184. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Systemic lupus erythematosus (rs4151115). MyGeneLog™. https://www.mygenelog.com/variants/rs4151115

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