Sensitive

High-grade serous epithelial ovarian cancer

SULT1B1 · rs4149419

Where this position leads

What the study found

Who was studied 15,588 European ancestry cases, 105,724 European ancestry controls.

The effect Each copy of the T allele carried 0.93 times the odds of High-grade serous epithelial ovarian cancer (95% confidence interval 0.9-0.95); p = 3 × 10⁻⁸.

How common The T allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 4, band 4q13.3 — in the 3′ untranslated region of SULT1B1.

What each result means

G/G No copy of the version the research linked to High-grade serous epithelial ovarian cancer. This is the starting point the study compared everyone against.

G/T One copy of the version the research linked to High-grade serous epithelial ovarian cancer. That is a smaller link than two copies.

T/T Two copies of the version the research linked to High-grade serous epithelial ovarian cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions

Dareng EO, Coetzee SG, Tyrer JP, Peng PC, Rosenow W, Chen S, Davis BD, Dezem FS, Seo JH, Nameki R, Reyes AL, Aben KKH

and 141 more — show all

Anton-Culver H, Antonenkova NN, Aravantinos G, Bandera EV, Beane Freeman LE, Beckmann MW, Beeghly-Fadiel A, Benitez J, Bernardini MQ, Bjorge L, Black A, Bogdanova NV, Bolton KL, Brenton JD, Budzilowska A, Butzow R, Cai H, Campbell I, Cannioto R, Chang-Claude J, Chanock SJ, Chen K, Chenevix-Trench G, Chiew YE, Cook LS, DeFazio A, Dennis J, Doherty JA, Dörk T, du Bois A, Dürst M, Eccles DM, Ene G, Fasching PA, Flanagan JM, Fortner RT, Fostira F, Gentry-Maharaj A, Giles GG, Goodman MT, Gronwald J, Haiman CA, Håkansson N, Heitz F, Hildebrandt MAT, Høgdall E, Høgdall CK, Huang RY, Jensen A, Jones ME, Kang D, Karlan BY, Karnezis AN, Kelemen LE, Kennedy CJ, Khusnutdinova EK, Kiemeney LA, Kjaer SK, Kupryjanczyk J, Labrie M, Lambrechts D, Larson MC, Le ND, Lester J, Li L, Lubiński J, Lush M, Marks JR, Matsuo K, May T, McLaughlin JR, McNeish IA, Menon U, Missmer S, Modugno F, Moffitt M, Monteiro AN, Moysich KB, Narod SA, Nguyen-Dumont T, Odunsi K, Olsson H, Onland-Moret NC, Park SK, Pejovic T, Permuth JB, Piskorz A, Prokofyeva D, Riggan MJ, Risch HA, Rodríguez-Antona C, Rossing MA, Sandler DP, Setiawan VW, Shan K, Song H, Southey MC, Steed H, Sutphen R, Swerdlow AJ, Teo SH, Terry KL, Thompson PJ, Vestrheim Thomsen LC, Titus L, Trabert B, Travis R, Tworoger SS, Valen E, Van Nieuwenhuysen E, Edwards DV, Vierkant RA, Webb PM, Weinberg CR, Weise RM, Wentzensen N, White E, Winham SJ, Wolk A, Woo YL, Wu AH, Yan L, Yannoukakos D, Zeinomar N, Zheng W, Ziogas A, Berchuck A, Goode EL, Huntsman DG, Pearce CL, Ramus SJ, Sellers TA, Freedman ML, Lawrenson K, Schildkraut JM, Hazelett D, Plummer JT, Kar S, Jones MR, Pharoah PDP, Gayther SA

AOCS Group · OPAL Study Group · Ovarian Cancer Association Consortium (OCAC)

American journal of human genetics · 2024 · PMID 38723632

Questions about rs4149419

What is rs4149419?

rs4149419 is a single position in the genome, in or near the SULT1B1 gene. Published research associates it with high-grade serous epithelial ovarian cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4149419 linked to?

On MyGeneLog this position is linked to Ovarian Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs4149419 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4149419 come from?

GWAS Catalog, American journal of human genetics 2024, PMID:38723632. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

High-grade serous epithelial ovarian cancer (rs4149419). MyGeneLog™. https://www.mygenelog.com/variants/rs4149419

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