Sensitive

Movement related adverse drug reaction to aripiprazole in schizophrenia

SLC22A8 · rs4149181

Where this position leads

Condition: Schizophrenia

rs4149181 Condition: Schizophrenia Schizophrenia Condition rs4149181 rs4149181 SLC22A8

What the study found

Who was studied 384 Han Chinese ancestry individuals.

The effect Each copy of the G allele shifted the measure 4.44 higher (95% confidence interval 2.91-5.96); p = 2 × 10−8.

Where it sits Chromosome 11, band 11q12.3 — in an intron of SLC22A8.

What each result means

A/A No copy of the version the research linked to Movement related adverse drug reaction to aripiprazole in schizophrenia. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Movement related adverse drug reaction to aripiprazole in schizophrenia. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Movement related adverse drug reaction to aripiprazole in schizophrenia. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs4149181

What is rs4149181?

rs4149181 is a single position in the genome, in or near the SLC22A8 gene. Published research associates it with movement related adverse drug reaction to aripiprazole in schizophrenia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4149181 linked to?

On MyGeneLog this position is linked to Schizophrenia. The research behind each link, and its sources, are set out on that condition page.

Does having rs4149181 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4149181 come from?

GWAS Catalog, Schizophrenia (Heidelberg, Germany) 2023, PMID:37491364. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Movement related adverse drug reaction to aripiprazole in schizophrenia (rs4149181). MyGeneLog™. https://www.mygenelog.com/variants/rs4149181

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