TAP2 · rs4148876
Where this position leads
Condition: Psoriasis
What the study found
Who was studied 26,279 European ancestry cases, 442,230 European ancestry controls, 2,590 South Asian ancestry cases, 1,720 South Asian ancestry controls.
The effect Each copy of the A allele shifted the measure 0.156 lower (95% confidence interval 0.13-0.19); p = 6 × 10−14.
Where it sits Chromosome 6, band 6p21.32 — a missense change in TAP2.
What ClinVar records
Classification
Benign/Likely benign for MHC class I deficiency; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-02-04.
ClinVar record 1164495 NM_001290043.2(TAP2):c.1951C>T (p.Arg651Cys)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs4148876 is a single position in the genome, in or near the TAP2 gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Journal of translational medicine 2025, PMID:39885523. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Psoriasis (rs4148876). MyGeneLog™. https://www.mygenelog.com/variants/rs4148876