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Positive affect

near BMAL1 · rs4146385

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 410,603 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.00992 lower (95% confidence interval 0.0073-0.0125); p = 9 × 10⁻¹⁴.

How common The A allele had a frequency of about 57% in the people studied.

Where it sits Chromosome 11, band 11p15.3 — between genes, 6.3 kb from BMAL1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Positive affect compared to the general population.

A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Positive affect.

T/T Published research associates this genotype with typical/baseline likelihood of Positive affect — no copies of the reported risk allele.

Source

Multivariate genome-wide analyses of the well-being spectrum

Baselmans BML, Jansen R, Ip HF, van Dongen J, Abdellaoui A, van de Weijer MP, Bao Y, Smart M, Kumari M, Willemsen G, Hottenga JJ, Boomsma DI

and 3 more — show all

de Geus EJC, Nivard MG, Bartels M

BIOS consortium · Social Science Genetic Association Consortium

Nature genetics · 2019 · PMID 30643256

Questions about rs4146385

What is rs4146385?

rs4146385 is a single position in the genome, in or near the near BMAL1 gene. Published research associates it with positive affect. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4146385 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4146385 come from?

GWAS Catalog, Nat Genet 2019, PMID:30643256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Positive affect (rs4146385). MyGeneLog™. https://www.mygenelog.com/variants/rs4146385

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