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Who was studied 73,265 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.186 lower (95% confidence interval 0.13-0.25); p = 1 × 10−9.
Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of ZDHHC20P2.
What each result means
A/ANo copy of the version the research linked to Rosacea symptom severity. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Rosacea symptom severity. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Rosacea symptom severity. That is the strongest link of the three results. A link in a study is not a diagnosis.
Human molecular genetics · 2018 · PMID 29771307 · open access
Questions about rs4143333
What is rs4143333?
rs4143333 is a single position in the genome, in or near the HLA-C gene. Published research associates it with rosacea symptom severity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4143333 linked to?
On MyGeneLog this position is linked to Rosacea. The research behind each link, and its sources, are set out on that condition page.
Does having rs4143333 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4143333 come from?
GWAS Catalog, Hum Mol Genet 2018, PMID:29771307. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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