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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 31,023 Caucasian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 6.25 (zscore) higher; p = 4 × 10−10.
How common The G allele had a frequency of about 76% in the people studied.
Where it sits Chromosome 2, band 2q24.3 — in an intron of CERS6.
What each result means
A/ANo copy of the version the research linked to Sphingomyeline C16:0 levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Sphingomyeline C16:0 levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Sphingomyeline C16:0 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs4143279 is a single position in the genome, in or near the CERS6 gene. Published research associates it with sphingomyeline c16:0 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4143279 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4143279 come from?
GWAS Catalog, Nature genetics 2021, PMID:33414548. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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