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Its strongest genetic-study result is p = 10−15, with 3 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 811,539 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0105 lower (95% confidence interval 0.0072-0.0138); p = 8 × 10−10.
How common The A allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 7, band 7q31.33 — in an intron of GRM8.
How common each version is
AG
KoreanKRGDB
A 74.1% · G 25.9%
KoreanKorea4K
A 74.0% · G 26.0%
KoreanKorea1K
A 72.6% · G 27.4%
Japanese ToMMo
A 76.7% · G 23.3%
Vietnamese
A 75.0% · G 25.0%
World gnomAD
A 55.0% · G 45.0%
World 1000 Genomes
A 54.5% · G 45.5%
World TOPMed
A 54.2% · G 45.8%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What each result means
A/ATwo copies of the version the research linked to Highest math class taken (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Highest math class taken (MTAG). That is a smaller link than two copies.
G/GNo copy of the version the research linked to Highest math class taken (MTAG). This is the starting point the study compared everyone against.
rs4141410 is a single position in the genome, in or near the GRM8 gene. Published research associates it with highest math class taken (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4141410 linked to?
On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.
Does having rs4141410 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4141410 come from?
GWAS Catalog, Nat Genet 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Highest math class taken (MTAG) (rs4141410). MyGeneLog™. https://www.mygenelog.com/variants/rs4141410