Sensitive

Urine cysteine levels in chronic kidney disease

FMO4 · rs4140632

What the study found

Who was studied 4,908 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.076 lower (95% confidence interval 0.058-0.094); p = 6 × 10−16.

How common The C allele had a frequency of about 44% in the people studied.

Where it sits Chromosome 1, band 1q24.3 — in an intron of FMO4.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Urine cysteine levels in chronic kidney disease — no copies of the reported risk allele.
A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Urine cysteine levels in chronic kidney disease.
C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Urine cysteine levels in chronic kidney disease compared to the general population.
Source

Questions about rs4140632

What is rs4140632?

rs4140632 is a single position in the genome, in or near the FMO4 gene. Published research associates it with urine cysteine levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4140632 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4140632 come from?

GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Urine cysteine levels in chronic kidney disease (rs4140632). MyGeneLog™. https://www.mygenelog.com/variants/rs4140632

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