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Shingles

TNXB · rs41316748

Where this position leads

Conditions: Tonsillectomy (Throat Infection Susceptibility), Shingles

rs41316748 Condition: Tonsillectomy (Throat Infection Susceptibility) Tonsillectomy (Throat Infection Sus… Condition Condition: Shingles Shingles Condition rs41316748 rs41316748 TNXB

What the study found

Who was studied 16,711 European ancestry cases, 118,152 European ancestry controls.

The effect Each copy of the C allele carried 1.19 times the odds of Shingles (95% confidence interval 1.15-1.23); p = 1 × 10−12.

How common The C allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in an intron of TNXB.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Shingles compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Shingles.
T/T Published research associates this genotype with typical/baseline likelihood of Shingles — no copies of the reported risk allele.
Source
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections
Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA
Nature communications · 2017 · PMID 28928442 · open access

Questions about rs41316748

What is rs41316748?

rs41316748 is a single position in the genome, in or near the TNXB gene. Published research associates it with shingles. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs41316748 linked to?

On MyGeneLog this position is linked to Tonsillectomy (Throat Infection Susceptibility), Shingles. The research behind each link, and its sources, are set out on that condition page.

Does having rs41316748 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs41316748 come from?

GWAS Catalog, Nat Commun 2017, PMID:28928442. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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