RTEL1-TNFRSF6B · rs41309931
Where this position leads
Condition: EGFR Mutation-Positive Lung Adenocarcinoma
What the study found
Who was studied 13,292 European ancestry cases, 67,596 European ancestry controls; replicated in 7,042 European ancestry cases, 13,599 European ancestry controls.
The effect Each copy of the T allele carried 1.16 times the odds of Lung adenocarcinoma (95% confidence interval 1.119-1.211); p = 8 × 10−14.
How common The T allele had a frequency of about 12% in the people studied.
Where it sits Chromosome 20, band 20q13.33 — inside RTEL1-TNFRSF6B.
What ClinVar records
Classification
Benign for Dyskeratosis congenita, Dyskeratosis congenita, autosomal recessive 5, Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 3; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 11 submitters), last evaluated 2026-02-04.
ClinVar record 403403 NM_001283009.2(RTEL1):c.3499+5G>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs41309931 is a single position in the genome, in or near the RTEL1-TNFRSF6B gene. Published research associates it with lung adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to EGFR Mutation-Positive Lung Adenocarcinoma. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nature communications 2024, PMID:39366959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung adenocarcinoma (rs41309931). MyGeneLog™. https://www.mygenelog.com/variants/rs41309931