SPARC · rs41290587
Where this position leads
Conditions: Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight
What the study found
Who was studied 806,834 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.0776 higher (95% confidence interval 0.055-0.1); p = 3 × 10−11.
How common The T allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 5, band 5q33.1 — a missense change in SPARC.
What ClinVar records
Classification
Conflicting classifications of pathogenicity for Osteogenesis imperfecta, Inborn genetic diseases, SPARC-related disorder; criteria provided, conflicting classifications (1 of 4 stars, 8 submitters), last evaluated 2026-02-01.
ClinVar record 785151 NM_003118.4(SPARC):c.733G>A (p.Gly245Arg)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs41290587 is a single position in the genome, in or near the SPARC gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Waist-to-Hip Ratio (Body Fat Distribution), Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hum Mol Genet 2018, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body mass index (rs41290587). MyGeneLog™. https://www.mygenelog.com/variants/rs41290587