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Who was studied 46,768 European ancestry low tanning cases, 74,528 European ancestry moderate and high tanning controls; replicated in 15,547 European ancestry low tanning cases, 39,835 European moderate and high tanning ancestry controls.
The effect
Each copy of the C allele shifted the measure 0.187 higher (95% confidence interval 0.1-0.27); p = 1 × 10−79.
Where it sits Chromosome 11, band 11q14.3 — in an intron of GRM5.
What each result means
C/CTwo copies of the version the research linked to Low tan response. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Low tan response. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Low tan response. This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 29739929 · open access
Questions about rs4121827
What is rs4121827?
rs4121827 is a single position in the genome, in or near the GRM5 gene. Published research associates it with low tan response. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4121827 linked to?
On MyGeneLog this position is linked to Sun Sensitivity, Freckling and Skin Cancer Risk. The research behind each link, and its sources, are set out on that condition page.
Does having rs4121827 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4121827 come from?
GWAS Catalog, Nat Commun 2018, PMID:29739929. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 231812218Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI8Microsoft · Copilot1Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others8Total23Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Low tan response (rs4121827). MyGeneLog™. https://www.mygenelog.com/variants/rs4121827