0 18152325Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot5Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others5Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,311 East Asian ancestry cases, 7,780 East Asian ancestry controls.
The effect
Each copy of the T allele carried 0.53 times the odds of Pediatric steroid sensitive nephrotic syndrome (95% confidence interval 0.47-0.6); p = 7 × 10−25.
Where it sits Chromosome 19, band 19q13.12 — in an intron of NPHS1.
What ClinVar records
ClassificationBenign for Finnish congenital nephrotic syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 3 submitters), last evaluated 2021-06-10.
ClinVar record 1172965NM_004646.4(NPHS1):c.397+61A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Pediatric steroid sensitive nephrotic syndrome. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Pediatric steroid sensitive nephrotic syndrome. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Pediatric steroid sensitive nephrotic syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2023 · PMID 37120605 · open access
Questions about rs412175
What is rs412175?
rs412175 is a single position in the genome, in or near the NPHS1 gene. Published research associates it with pediatric steroid sensitive nephrotic syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs412175 linked to?
On MyGeneLog this position is linked to Childhood Steroid-Sensitive Nephrotic Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs412175 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs412175 come from?
GWAS Catalog, Nature communications 2023, PMID:37120605. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 18152325Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot5Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others5Total18Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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