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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 85,204 European or unknown ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0454 SD unit higher (95% confidence interval 0.034-0.057); p = 1 × 10−15.
Where it sits Chromosome 1, band 1q25.1 — in an intron of TNFSF4.
What each result means
A/ATwo copies of the version the research linked to Immunoglobulin A levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Immunoglobulin A levels. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Immunoglobulin A levels. This is the starting point the study compared everyone against.
rs4090390 is a single position in the genome, in or near the TNFSF4 gene. Published research associates it with immunoglobulin a levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4090390 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4090390 come from?
GWAS Catalog, Genes and immunity 2026, PMID:42642615. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 624Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others4Total6Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Immunoglobulin A levels (rs4090390). MyGeneLog™. https://www.mygenelog.com/variants/rs4090390