Standard
Smoking initiation
CASC15 · rs4083995
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 3,382,012 European ancestry, East Asian ancestry, Hispanic or Latin American, African ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.00376 higher (95% confidence interval 0.0022-0.0053); p = 3 × 10−10.
How common The T allele had a frequency of about 62% in the people studied.
Where it sits Chromosome 6, band 6p22.3 — inside CASC15.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of Smoking initiation — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Smoking initiation.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Smoking initiation compared to the general population.
Source
Genetic diversity fuels gene discovery for tobacco and alcohol use
Saunders GRB,
Wang X,
Chen F,
Jang SK,
Liu M,
Wang C,
Gao S,
Jiang Y,
Khunsriraksakul C,
Otto JM,
Addison C,
Akiyama M
and 205 more — show all
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Aliev F,
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Arnett DK,
Ashley-Koch AE,
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Cheng I,
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Meyers DA,
Millwood IY,
Mitchell BD,
Mohlke KL,
Moll M,
Montasser ME,
Morrison AC,
Mulas A,
Nielsen JB,
North KE,
Oelsner EC,
Okada Y,
Orrù V,
Palmer ND,
Palviainen T,
Pandit A,
Park SL,
Peters U,
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Peyser PA,
Polderman TJC,
Rafaels N,
Redline S,
Reed RM,
Reiner AP,
Rice JP,
Rich SS,
Richmond NE,
Roan C,
Rotter JI,
Rueschman MN,
Runarsdottir V,
Saccone NL,
Schwartz DA,
Shadyab AH,
Shi J,
Shringarpure SS,
Sicinski K,
Skogholt AH,
Smith JA,
Smith NL,
Sotoodehnia N,
Stallings MC,
Stefansson H,
Stefansson K,
Stitzel JA,
Sun X,
Syed M,
Tal-Singer R,
Taylor AE,
Taylor KD,
Telen MJ,
Thai KK,
Tiwari H,
Turman C,
Tyrfingsson T,
Wall TL,
Walters RG,
Weir DR,
Weiss ST,
White WB,
Whitfield JB,
Wiggins KL,
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Xu H,
Yanek LR,
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Nature · 2022 · PMID 36477530 · open access
Questions about rs4083995
What is rs4083995?
rs4083995 is a single position in the genome, in or near the CASC15 gene. Published research associates it with smoking initiation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs4083995 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4083995 come from?
GWAS Catalog, Nature 2022, PMID:36477530. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Smoking initiation (rs4083995). MyGeneLog™. https://www.mygenelog.com/variants/rs4083995
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