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Childhood obesity

ADCY3 · rs4077678

Where this position leads

What the study found

Who was studied 8,613 European ancestry cases, 3,213 African American cases, 69 Moroccan ancestry cases, 986 Hispanic/Latino cases, 124 East Asian ancestry cases, 12,696 European ancestry controls, 1,392 African American controls, 64 Moroccan ancestry controls, 993 Hispanic/Latino controls, 454 East Asian ancestry controls.

The effect Each copy of the C allele shifted the measure 0.131 lower (95% confidence interval 0.093-0.168); p = 1 × 10⁻¹¹.

Where it sits Chromosome 2, band 2p23.3 — in an intron of ADCY3.

What each result means

C/C Two copies of the version the research linked to Childhood obesity. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/G One copy of the version the research linked to Childhood obesity. That is a smaller link than two copies.

G/G No copy of the version the research linked to Childhood obesity. This is the starting point the study compared everyone against.

Source

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

Bradfield JP, Vogelezang S, Felix JF, Chesi A, Helgeland Ø, Horikoshi M, Karhunen V, Lowry E, Cousminer DL, Ahluwalia TS, Thiering E, Boh ET

and 87 more — show all

Zafarmand MH, Vilor-Tejedor N, Wang CA, Joro R, Chen Z, Gauderman WJ, Pitkänen N, Parra EJ, Fernandez-Rhodes L, Alyass A, Monnereau C, Curtin JA, Have CT, McCormack SE, Hollensted M, Frithioff-Bøjsøe C, Valladares-Salgado A, Peralta-Romero J, Teo YY, Standl M, Leinonen JT, Holm JC, Peters T, Vioque J, Vrijheid M, Simpson A, Custovic A, Vaudel M, Canouil M, Lindi V, Atalay M, Kähönen M, Raitakari OT, van Schaik BDC, Berkowitz RI, Cole SA, Voruganti VS, Wang Y, Highland HM, Comuzzie AG, Butte NF, Justice AE, Gahagan S, Blanco E, Lehtimäki T, Lakka TA, Hebebrand J, Bonnefond A, Grarup N, Froguel P, Lyytikäinen LP, Cruz M, Kobes S, Hanson RL, Zemel BS, Hinney A, Teo KK, Meyre D, North KE, Gilliland FD, Bisgaard H, Bustamante M, Bonnelykke K, Pennell CE, Rivadeneira F, Uitterlinden AG, Baier LJ, Vrijkotte TGM, Heinrich J, Sørensen TIA, Saw SM, Pedersen O, Hansen T, Eriksson J, Widén E, McCarthy MI, Njølstad PR, Power C, Hyppönen E, Sebert S, Brown CD, Järvelin MR, Timpson NJ, Johansson S, Hakonarson H, Jaddoe VWV, Grant SFA

Early Growth Genetics Consortium

Human molecular genetics · 2019 · PMID 31504550

Questions about rs4077678

What is rs4077678?

rs4077678 is a single position in the genome, in or near the ADCY3 gene. Published research associates it with childhood obesity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4077678 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs4077678 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4077678 come from?

GWAS Catalog, Hum Mol Genet 2019, PMID:31504550. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Childhood obesity (rs4077678). MyGeneLog™. https://www.mygenelog.com/variants/rs4077678

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