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Forced vital capacity (FVC)

LOXL1 · rs4077284

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

rs4077284 Condition: Pulmonary Function (Lung Capacity) Pulmonary Function (Lung Capacity) Condition rs4077284 rs4077284 LOXL1

What the study found

Who was studied 129,680 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0141 higher (95% confidence interval 0.0092-0.019); p = 2 × 10−8.

Where it sits Chromosome 15, band 15q24.1 — in an intron of LOXL1.

What each result means

A/A Two copies of the version the research linked to Forced vital capacity (FVC). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Forced vital capacity (FVC). That is a smaller link than two copies.
G/G No copy of the version the research linked to Forced vital capacity (FVC). This is the starting point the study compared everyone against.
Source

Questions about rs4077284

What is rs4077284?

rs4077284 is a single position in the genome, in or near the LOXL1 gene. Published research associates it with forced vital capacity (fvc). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4077284 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

Does having rs4077284 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4077284 come from?

GWAS Catalog, Nature genetics 2026, PMID:41565855. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Forced vital capacity (FVC) (rs4077284). MyGeneLog™. https://www.mygenelog.com/variants/rs4077284

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