Standard

Percentage of FA2G1 in total neutral plasma glycans (GPn) (GP61)

near TMEM121 · rs4074453

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 10,172 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.234 higher (95% confidence interval 0.19-0.28); p = 2 × 10⁻²⁸.

How common The C allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 14, band 14q32.33 — between genes, 2 kb from TMEM121.

What each result means

C/C Two copies of the version the research linked to Percentage of FA2G1 in total neutral plasma glycans (GPn) (GP61). That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Percentage of FA2G1 in total neutral plasma glycans (GPn) (GP61). That is a smaller link than two copies.

T/T No copy of the version the research linked to Percentage of FA2G1 in total neutral plasma glycans (GPn) (GP61). This is the starting point the study compared everyone against.

Source

A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins

Sharapov S, Timoshchuk A, Zaytseva O, Maslov DE, Soplenkova A, Elgaeva EE, Tiys ES, Mangino M, Wittenbecher C, Karssen L, Timofeeva M, Nostaeva A

and 19 more — show all

Vuckovic F, Trbojević-Akmačić I, Štambuk T, Feoktistova S, Potapova NA, Voroshilova V, Williams F, Primorac D, Van Zundert J, Georges M, Suhre K, Allegri M, Chaturvedi N, Dunlop M, Schulze MB, Spector T, Tsepilov YA, Lauc G, Aulchenko YS

Nature communications · 2025 · PMID 40593539 · open access

Questions about rs4074453

What is rs4074453?

rs4074453 is a single position in the genome, in or near the near TMEM121 gene. Published research associates it with percentage of fa2g1 in total neutral plasma glycans (gpn) (gp61). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs4074453 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4074453 come from?

GWAS Catalog, Nature communications 2025, PMID:40593539. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Percentage of FA2G1 in total neutral plasma glycans (GPn) (GP61) (rs4074453). MyGeneLog™. https://www.mygenelog.com/variants/rs4074453

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