Who was studied 349,856 European ancestry individuals, 95,119 East Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0678 higher (95% confidence interval 0.064-0.072); p = 1 × 10−222.
Where it sits Chromosome 3, band 3q21.3 — between genes, 10.4 kb from LINC01565.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Monocyte count — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Monocyte count.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Monocyte count compared to the general population.
rs4045811 is a single position in the genome, in or near the near LINC01565 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs4045811 linked to?
On MyGeneLog this position is linked to Monocyte Count. The research behind each link, and its sources, are set out on that condition page.
Does having rs4045811 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4045811 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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