Standard

Dental caries

near HLA-B · rs402175

Where this position leads

Condition: Dental Caries

rs402175 Condition: Dental Caries Dental Caries Condition rs402175 rs402175 near HLA-B

What the study found

Who was studied 30,859 Japanese ancestry cases, 14,666 Japanese ancestry controls, 26,792 European or unknown ancestry individuals, 77,714 European or unknown ancestry cases, 383,317 European or unknown ancestry controls.

The effect Each copy of the A allele shifted the measure 8.67 z score higher; p = 4 × 10−18.

Where it sits Chromosome 6, band 6p21.33 — between genes, 12.9 kb from HLA-B.

What each result means

A/A Two copies of the version the research linked to Dental caries. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Dental caries. That is a smaller link than two copies.
G/G No copy of the version the research linked to Dental caries. This is the starting point the study compared everyone against.
Source

Questions about rs402175

What is rs402175?

rs402175 is a single position in the genome, in or near the near HLA-B gene. Published research associates it with dental caries. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs402175 linked to?

On MyGeneLog this position is linked to Dental Caries. The research behind each link, and its sources, are set out on that condition page.

Does having rs402175 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs402175 come from?

GWAS Catalog, BMC oral health 2024, PMID:39192244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Dental caries (rs402175). MyGeneLog™. https://www.mygenelog.com/variants/rs402175

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