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Who was studied 20,901 European ancestry cases, 282,881 European ancestry controls.
The effect
Each copy of the A allele carried 1.09 times the odds of Osteoarthritis of the hand (95% confidence interval 1.05971123-1.112493123); p = 4 × 10−11.
How common The A allele had a frequency of about 61% in the people studied.
Where it sits Chromosome 11, band 11p15.3 — in an intron of TEAD1.
What each result means
A/ATwo copies of the version the research linked to Osteoarthritis of the hand. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Osteoarthritis of the hand. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Osteoarthritis of the hand. This is the starting point the study compared everyone against.
rs3993110 is a single position in the genome, in or near the TEAD1 gene. Published research associates it with osteoarthritis of the hand. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3993110 linked to?
On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.
Does having rs3993110 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3993110 come from?
GWAS Catalog, Cell 2021, PMID:34450027. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total2Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Osteoarthritis of the hand (rs3993110). MyGeneLog™. https://www.mygenelog.com/variants/rs3993110