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Who was studied 39,664 European ancestry cases, 119,158 European ancestry controls, 2,438 African ancestry cases, 62,112 African ancestry controls; replicated in 17,417 European ancestry cases, 13,599 European ancestry controls, 1,987 African ancestry cases, 3,779 African ancestry controls.
The effect
Each copy of the A allele carried 1.06 times the odds of Lung cancer (95% confidence interval 1.043-1.076); p = 1 × 10−13.
How common The A allele had a frequency of about 50% in the people studied.
Where it sits Chromosome 6, band 6q27 — between genes, 17.2 kb from RNASET2.
What each result means
A/ATwo copies of the version the research linked to Lung cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Lung cancer. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Lung cancer. This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39366959 · open access
Questions about rs398278
What is rs398278?
rs398278 is a single position in the genome, in or near the near RNASET2 gene. Published research associates it with lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs398278 linked to?
On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs398278 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs398278 come from?
GWAS Catalog, Nature communications 2024, PMID:39366959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 5122Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total5Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Lung cancer (rs398278). MyGeneLog™. https://www.mygenelog.com/variants/rs398278