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White blood cell count

GSTM2 · rs398145

Where this position leads

Condition: Blood Cell Counts

rs398145 Condition: Blood Cell Counts Blood Cell Counts Condition rs398145 rs398145 GSTM2

What the study found

Who was studied 16,201 African American or Afro-Caribbean individuals.

The effect Each copy of the A allele shifted the measure 0.113 higher (95% confidence interval 0.089-0.136); p = 3 × 10−21.

How common The A allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 1, band 1p13.3 — in an intron of GSTM2.

What each result means

A/A Two copies of the version the research linked to White blood cell count. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to White blood cell count. That is a smaller link than two copies.
G/G No copy of the version the research linked to White blood cell count. This is the starting point the study compared everyone against.
Source

Questions about rs398145

What is rs398145?

rs398145 is a single position in the genome, in or near the GSTM2 gene. Published research associates it with white blood cell count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs398145 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs398145 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs398145 come from?

GWAS Catalog, BMC genomics 2021, PMID:34107879. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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White blood cell count (rs398145). MyGeneLog™. https://www.mygenelog.com/variants/rs398145

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