Sensitive

Hereditary breast ovarian cancer syndrome

BRCA1 · rs397509331

Where this position leads

Strength of the evidence

4 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 3 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Hereditary breast ovarian cancer syndrome, Breast-ovarian cancer, familial, susceptibility to, 1, Hereditary cancer-predisposing syndrome; reviewed by expert panel (3 of 4 stars, 6 submitters), last evaluated 2016-10-18. ClinVar record 55745 NM_007294.4(BRCA1):c.89T>A (p.Leu30Ter)

Classification Uncertain significance for Breast-ovarian cancer, familial, susceptibility to, 1, Hereditary cancer-predisposing syndrome; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2025-05-14. ClinVar record 865102 NM_007294.4(BRCA1):c.89T>C (p.Leu30Ser)

Classification Uncertain significance for Breast-ovarian cancer, familial, susceptibility to, 1, Hereditary breast ovarian cancer syndrome; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2024-10-15. ClinVar record 865103 NM_007294.4(BRCA1):c.89T>G (p.Leu30Trp)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A No copy of the version ClinVar lists as disease-causing for Hereditary breast ovarian cancer syndrome. This is the usual result. (ClinVar VCV000055745, reviewed by expert panel)

A/T One copy of the version ClinVar lists as disease-causing for Hereditary breast ovarian cancer syndrome. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV000055745, reviewed by expert panel)

T/T Two copies of the version ClinVar lists as disease-causing for Hereditary breast ovarian cancer syndrome. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000055745, reviewed by expert panel)

Source: ClinVar VCV000055745, reviewed by expert panel

Questions about rs397509331

What is rs397509331?

rs397509331 is a single position in the genome, in or near the BRCA1 gene. Published research associates it with hereditary breast ovarian cancer syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs397509331 linked to?

On MyGeneLog this position is linked to Ovarian Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs397509331 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs397509331 come from?

ClinVar VCV000055745, reviewed by expert panel. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hereditary breast ovarian cancer syndrome (rs397509331). MyGeneLog™. https://www.mygenelog.com/variants/rs397509331

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