Polycystic ovary syndrome (adjusted for age and BMI)
DENND1A · rs3945628
2 37118124119Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity1Meta AI8Microsoft · Copilot1Amazon2Apple4China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others19Total37Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 482 European ancestry cases, 91,631 European ancestry controls; replicated in 2,137 European ancestry cases, 68,690 European ancestry controls.
The effect
Each copy of the C allele carried 1.38 times the odds of Polycystic ovary syndrome (adjusted for age and BMI) (95% confidence interval 1.23–1.54] ); p = 1 × 10−8.
How common The C allele had a frequency of about 7% in the people studied.
Where it sits Chromosome 9, band 9q33.3 — in an intron of DENND1A.
What each result means
C/CTwo copies of the version the research linked to Polycystic ovary syndrome (adjusted for age and BMI). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Polycystic ovary syndrome (adjusted for age and BMI). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Polycystic ovary syndrome (adjusted for age and BMI). This is the starting point the study compared everyone against.
Human reproduction (Oxford, England) · 2022 · PMID 34791234 · open access
Questions about rs3945628
What is rs3945628?
rs3945628 is a single position in the genome, in or near the DENND1A gene. Published research associates it with polycystic ovary syndrome (adjusted for age and bmi). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs3945628 linked to?
On MyGeneLog this position is linked to Polycystic Ovary Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs3945628 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3945628 come from?
GWAS Catalog, Hum Reprod 2021, PMID:34791234. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
2 37118124119Reads by AI crawlersClaude0ChatGPT0Google · Gemini1Perplexity1Meta AI8Microsoft · Copilot1Amazon2Apple4China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others19Total37Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Polycystic ovary syndrome (adjusted for age and BMI) (rs3945628). MyGeneLog™. https://www.mygenelog.com/variants/rs3945628